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Perhaps a more balanced comparison, less subject to indication bias, would be of second-line use of semaglutide with second-line use of a comparable antihyperglycemic medication such as sodium-glucose cotransporter 2 (SGLT2) inhibitors, according to the authors of an editorial accompanying the journal article
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I do anticipate that more will tread lightly.
A., & SURMOUNT-4 Investigators (2024)
Evidence supporting specific protocol structures remains limited, and individualized assessment is required before extrapolating research findings to clinical practice
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